Description

[S-(E)]-2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrrolidine (S-Eddp) is a high-purity chiral pyrrolidine derivative with a defined stereochemistry, serving as a critical intermediate in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control for creating active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) targets and receptor modulators.
• Chiral Ligand Precursor: Used in the development of asymmetric catalysts for enantioselective synthesis, improving the efficiency of producing single-isomer compounds.
• Agrochemical Research: Serves as a core structure for developing new herbicides, fungicides, and insecticides with enhanced specificity and activity.
• Material Science: Employed in the synthesis of advanced organic materials, including liquid crystals and polymers with specific optical or electronic properties.
• Academic & R&D: A valuable tool for medicinal chemistry and synthetic methodology research in university and corporate laboratories.
• Fine Chemical Synthesis: Used in multi-step syntheses of complex natural products, flavors, and fragrances.

Basic Information

Product Name	[S-(E)]-2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrrolidine (S-Eddp)
CAS No.	106293-57-6
Molecular Formula	C20H23N
Molecular Weight	277.41 g/mol
Synonyms	(S,E)-2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine; S-EDDP; (2E)-2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (S-form); 1,5-Dimethyl-3,3-diphenyl-2-ethylidenepyrrolidine (S,E)-; Pyrrolidine, 2-ethylidene-1,5-dimethyl-3,3-diphenyl-, (2E,5S)-; S-(E)-EDDP; (5S)-2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
EINECS	Contact for details

Quality Control

Our [S-(E)]-2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrrolidine (S-Eddp) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.