Description

[R-(E)]-2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrrolidine (R-Eddp) is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters because it serves as a critical building block for the production of complex, biologically active molecules, enabling precise stereochemical control. It is primarily needed by pharmaceutical research and development teams, as well as fine chemical manufacturers, for applications in asymmetric synthesis and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting the central nervous system.
• Asymmetric Catalysis: Used as a ligand precursor or a chiral auxiliary in catalytic reactions to induce enantioselectivity.
• Medicinal Chemistry Research: Employed in the discovery and optimization of new therapeutic agents requiring specific stereochemistry.
• Fine Chemical Synthesis: Integral to the multi-step synthesis of specialty chemicals where the (R,E)-configuration is essential for function.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	[R-(E)]-2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrrolidine (R-Eddp)
CAS No.	106293-55-4
Molecular Formula	C22H25N
Molecular Weight	303.44 g/mol
Synonyms	(R,E)-2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine; R-EDDP; (R)-2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine; (R,E)-EDDP; 1,5-Dimethyl-3,3-diphenyl-2-ethylidenepyrrolidine, (R,E)-; (2R,3E)-1,5-Dimethyl-3,3-diphenyl-2-ethylidenepyrrolidine
EINECS	Contact for details

Quality Control

Our [R-(E)]-2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrrolidine (R-Eddp) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.