Description

H-Gln-Amc CAS NO 105888-45-7 is a specialized glutamine-derived peptide building block, specifically the amide of L-glutamine. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure and function. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, proteomics research, and the development of novel therapeutic agents.

Application

• Peptide Synthesis: A key building block (amino acid derivative) for solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Research: Intermediate in the development of peptide-based drugs, enzyme inhibitors, and diagnostic agents.
• Bioconjugation: Used to introduce glutamine motifs or specific amide linkages into biomolecules for labeling or functionalization.
• Proteomics & Biochemistry: Serves as a substrate or inhibitor in enzymatic studies and biochemical assays.
• Chemical Biology: Tool compound for studying protein-protein interactions and signal transduction pathways.
• Material Science: Potential monomer for creating bio-inspired polymers and smart materials.

Basic Information

Product Name	H-Gln-Amc
CAS No.	105888-45-7
Molecular Formula	C8H15N3O3
Molecular Weight	201.22 g/mol
Synonyms	L-Glutamine amide; H-Gln-NH2; Glutaminamide; 2-Amino-4-carbamoylbutanamide; (S)-2-Amino-4-carbamoylbutanamide; Fmoc-Gln(Trt)-OH related intermediate; Glutamine derivative; Peptide synthesis building block
EINECS	Contact for details

Quality Control

Our H-Gln-Amc is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. We provide Certificates of Analysis (COA) with detailed specifications for trace impurities, residual solvents, and assay value. Our quality commitment ensures material suitability for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: + Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.