Description

Corticotropin Releasing Hormone, Biotinyl-Ser(1)- CAS NO 105883-79-2 is a biotinylated analog of the neuropeptide corticotropin-releasing hormone (CRH), a key regulator of the hypothalamic-pituitary-adrenal (HPA) axis. This modified peptide is of significant value for advanced research and diagnostic applications due to its high-affinity binding properties, which are enhanced by the biotin tag for sensitive detection. It is primarily needed by pharmaceutical R&D teams, clinical research organizations, and diagnostic kit manufacturers focused on stress response, neuroendocrinology, and related therapeutic areas.

Application

• Biochemical Research: Used as a high-affinity ligand in receptor binding assays and studies of the HPA axis signaling pathways.
• Diagnostic Development: Serves as a critical component in the development of immunoassays (e.g., ELISA) and biosensors for detecting CRH or related biomarkers.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel CRH receptor antagonists or agonists for drug discovery.
• Neuroscience Studies: Facilitates research into stress, anxiety, depression, and other neurological disorders by enabling precise tracking and quantification of CRH interactions.
• Affinity Purification: Utilized in affinity chromatography columns or pull-down assays to isolate and study CRH-binding proteins or receptor complexes.
• Cell Imaging: Acts as a probe for fluorescence or electron microscopy when conjugated with streptavidin-linked reporters, allowing visualization of receptor localization.

Basic Information

Product Name	Corticotropin Releasing Hormone, Biotinyl-Ser(1)- CAS NO 105883-79-2
CAS No.	105883-79-2
Molecular Formula	C226H366N66O66S2
Molecular Weight	~5060.9 g/mol
Synonyms	Biotinyl-CRH; Biotinylated Corticotropin-Releasing Hormone; Biotin-CRH; Biotinyl-Ser1-CRH; CRH, Biotinyl-Ser(1)-; Biotinylated CRF; Biotin-Corticotropin Releasing Factor; Biotin-Ser1-Corticotropin Releasing Factor
EINECS	Contact for details

Quality Control

Our Corticotropin Releasing Hormone, Biotinyl-Ser(1)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing purity, peptide content, and biotin incorporation ratio are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.