Description

L-Threo Lyso-Sphingomyelin (D18:1) is a specific, high-purity sphingolipid derivative, a key intermediate in lipid metabolism research and pharmaceutical development. This compound is critical for studying cellular signaling pathways, membrane dynamics, and the biochemical mechanisms underlying various diseases. It is essential for researchers and manufacturers in the life sciences, particularly those developing advanced lipid-based therapeutics, diagnostic standards, and high-value biochemical reagents.

Application

• Biochemical Research Standard: Used as a certified reference material (CRM) for quantitative analysis of sphingolipids in biological samples via LC-MS/MS.
• Pharmaceutical Development: Serves as a critical intermediate and analytical standard in the R&D of novel therapeutics targeting metabolic disorders and lysosomal storage diseases.
• Diagnostic Reagent Manufacturing: Employed in the production of calibrators and controls for clinical diagnostic kits measuring lysosphingolipids.
• Cell Biology Studies: Applied in research to investigate the role of lyso-sphingomyelin in cell signaling, apoptosis, and membrane biophysics.
• Lipidomics: A vital component in lipidomic profiling studies to understand lipid metabolism and identify disease biomarkers.
• Enzyme Activity Assays: Used as a specific substrate for studying the activity of enzymes like acid sphingomyelinase (ASM).

Basic Information

Product Name	L-Threo Lyso-Sphingomyelin (D18:1)
CAS No.	105615-55-2
Molecular Formula	C23H49N2O6P
Molecular Weight	480.62 g/mol
Synonyms	Lyso-Sphingomyelin (d18:1); N-Acylsphingosine Phosphocholine; Sphingosylphosphorylcholine; (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydrogen Phosphate) 2-(Trimethylammonio)ethyl Ester; Lysosphingomyelin; LSM; LysoSM; SPC; D-erythro-Sphingosylphosphorylcholine (lyso-form)
EINECS	Contact for details

Quality Control

Every batch of L-Threo Lyso-Sphingomyelin (D18:1) is produced and analyzed under strict quality management systems. We guarantee high chemical purity and structural integrity, supported by comprehensive analytical data including HPLC, MS, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the product should be handled in a dry environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.