Description

Dec-2-Ynoyl-Coenzyme A is a specialized biochemical reagent featuring a terminal alkyne moiety on the acyl chain. This compound is a critical tool for researchers studying fatty acid metabolism, enzyme mechanisms, and protein acylation. It is primarily utilized in biochemical research, pharmaceutical development, and metabolic pathway analysis to investigate the role of medium-chain fatty acyl-CoAs.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study acyl-CoA dehydrogenases, thioesterases, and other enzymes involved in fatty acid β-oxidation.
• Metabolic Pathway Analysis: Employed to probe and modulate specific steps in lipid metabolism within in vitro or cellular systems.
• Pharmaceutical Development: Serves as a key intermediate or tool compound in the discovery of drugs targeting metabolic disorders, such as diabetes or fatty acid oxidation defects.
• Enzyme Mechanism Studies: The alkyne functional group allows for "click chemistry" applications, enabling the tagging and visualization of protein acyltransferases or their protein targets.
• Proteomics: Can be used as an activity-based probe to profile the activity of enzymes that utilize acyl-CoA substrates.
• Academic & Industrial R&D: Fundamental research tool in universities, government labs, and biotech companies exploring lipid biology and energy metabolism.

Basic Information

Product Name	Dec-2-Ynoyl-Coenzyme A
CAS No.	105528-05-0
Molecular Formula	C31H50N7O17P3S
Molecular Weight	917.75 g/mol
Synonyms	2-Decynoyl-Coenzyme A; 2-Decynoyl-CoA; Dec-2-ynoyl-CoA; Coenzyme A, S-(2-decynoate); S-(2-Decynoyl)coenzyme A; 2-Decynoic Acid Coenzyme A Thioester; 2-Decynoyl-coenzyme A lithium salt (common salt form)
EINECS	Contact for details

Quality Control

Our Dec-2-Ynoyl-Coenzyme A is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity and identity confirmation via mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Functional in standard enzymatic assay (as applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.