Description

(S)-Tetrahydro-2H-Pyran-2-Carboxylic Acid is a high-value, chiral non-racemic building block essential for the synthesis of complex organic molecules. Its significance lies in its rigid, oxygen-containing heterocyclic structure, which serves as a key scaffold for introducing stereochemical complexity in pharmaceutical and agrochemical intermediates. This compound is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, fine chemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, antiviral agents, and enzyme inhibitors.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical reactions to produce enantiomerically pure compounds.
• Ligand and Catalyst Development: Serves as a starting material for the preparation of novel chiral ligands and organocatalysts used in homogeneous catalysis.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides where specific chirality impacts biological activity.
• Material Science: A building block for chiral polymers, liquid crystals, and other functional materials with specific optical properties.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects in contract research organizations (CROs) and CDMOs.

Basic Information

Product Name	(S)-Tetrahydro-2H-Pyran-2-Carboxylic Acid
CAS No.	105499-32-9
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	(S)-Tetrahydro-2H-pyran-2-carboxylic acid; (S)-Oxane-2-carboxylic acid; (S)-Tetrahydropyran-2-carboxylic acid; (2S)-Oxane-2-carboxylic acid; (S)-2-Carboxytetrahydropyran; (S)-THP-2-COOH; (S)-2-Tetrahydropyrancarboxylic acid; L-Tetrahydropyran-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-Tetrahydro-2H-Pyran-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. We provide comprehensive Certificates of Analysis (COA) with detailed specifications for enantiomeric excess (e.e.), chemical purity, and identity, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.