Description

14(R),15(S)-Epoxy-(5Z,8Z,11Z)-Eicosatrienoic Acid CAS NO 105304-92-5 is a specialized epoxy fatty acid derivative, serving as a key intermediate and reference standard in biochemical research. This compound is significant for its role as a precursor to bioactive lipid mediators involved in critical physiological pathways. It is primarily needed by research institutions and pharmaceutical companies focused on inflammation, vascular biology, and metabolic studies.

Application

• Biochemical Research Standard: Used as a high-purity reference compound for analytical method development and validation in lipidomics.
• Enzyme Substrate Studies: Acts as a specific substrate for studying the activity and inhibition of soluble epoxide hydrolase (sEH).
• Inflammation Pathway Analysis: Employed in research to investigate the biosynthesis and function of epoxy eicosatrienoic acids (EETs) and their role in inflammatory responses.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates targeting cardiovascular and inflammatory diseases.
• Cell Signaling Research: Utilized in cell culture and in vitro assays to elucidate the mechanisms of epoxy fatty acid-mediated cell signaling.
• Metabolite Identification: Aids in the identification and quantification of endogenous EET metabolites in biological samples via LC-MS/MS.

Basic Information

Product Name	14(R),15(S)-Epoxy-(5Z,8Z,11Z)-Eicosatrienoic Acid
CAS No.	105304-92-5
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	14(R),15(S)-EET; 14,15-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid; 14(R),15(S)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid; 14,15-EET; 14(R),15(S)-Epoxyeicosatrienoic Acid; (14R,15S)-Epoxy-(5Z,8Z,11Z)-eicosatrienoic Acid; 14,15-Epoxyeicosatrienoic Acid; Arachidonic Acid 14,15-Epoxide
EINECS	Contact for details

Quality Control

Our 14(R),15(S)-Epoxy-(5Z,8Z,11Z)-Eicosatrienoic Acid is produced under stringent quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to ensure high chemical and isomeric purity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency for research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity (Chiral HPLC)	≥ 98% (14R,15S)
Water Content (KF)	≤ 0.5%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.