Description

Dexamethasone β-D-Glucuronide Sodium Salt is a key conjugated metabolite of the potent synthetic glucocorticoid, dexamethasone. This compound is essential for research and development in pharmaceutical and clinical chemistry, serving as a critical reference standard and analytical tool. It is primarily used by scientists and quality control professionals in the pharmaceutical, biotechnology, and diagnostic industries for metabolite identification, pharmacokinetic studies, and method validation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of dexamethasone metabolites in drug development and bioanalytical studies.
• Metabolite Research: Critical for investigating the metabolic pathways, pharmacokinetics, and excretion profiles of dexamethasone in preclinical and clinical research.
• Biomarker Analysis: Employed in the development and validation of analytical methods (e.g., LC-MS/MS, HPLC) for detecting glucocorticoid metabolites in biological fluids.
• Diagnostic Kit Development: Serves as a calibrator or control in immunoassays and other diagnostic tests designed to monitor steroid levels.
• Enzymatic Study Substrate: Used in studies of glucuronidation enzymes (UGTs) to understand drug metabolism and potential drug-drug interactions.
• Quality Control (QC) Testing: Essential for pharmaceutical QC laboratories to ensure the accuracy and reliability of assays for dexamethasone and its related substances.

Basic Information

Product Name	Dexamethasone β-D-Glucuronide Sodium Salt
CAS No.	105088-08-2
Molecular Formula	C27H35NaO8
Molecular Weight	534.55 g/mol
Synonyms	Dexamethasone 21-β-D-Glucuronide Sodium Salt; Dexamethasone Glucuronide Sodium; Dexamethasone D-Glucuronide Sodium Salt; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-β-D-glucopyranosiduronic acid sodium salt; Sodium Dexamethasone Glucuronide; Dexamethasone Glucuronide Sodium Salt; Dexamethasone 21-Glucuronide Sodium
EINECS	Contact for details

Quality Control

Our Dexamethasone β-D-Glucuronide Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Solubility	Soluble in water, methanol; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.