Description

D-Glucose-[6-3H(N)] CAS NO 104903-05-1 is a radiolabeled form of D-glucose, specifically tritiated at the 6-position, serving as a critical tracer molecule in biochemical and pharmacological research. Its primary value lies in enabling precise metabolic pathway tracking, glucose uptake studies, and receptor binding assays without altering the native biochemical properties of the glucose molecule. This high-specific-activity compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors who require reliable tools for kinetic studies and diagnostic development.

Application

• Metabolic Research & Pathway Analysis: Used as a tracer to study glycolysis, gluconeogenesis, and the pentose phosphate pathway in cell cultures and tissue samples.
• Glucose Transport & Uptake Studies: Critical for quantifying glucose transporter (GLUT) activity and cellular uptake rates in normal and diseased states (e.g., cancer, diabetes).
• Drug Discovery & Development: Employed in high-throughput screening assays to evaluate the efficacy of novel therapeutic compounds targeting glucose metabolism.
• Diagnostic Agent Development: Acts as a key component in the research and development of radiopharmaceuticals and imaging agents for PET scan correlation studies.
• Enzymology Studies: Serves as a substrate for investigating the kinetics and mechanisms of enzymes like hexokinase and glucose-6-phosphate dehydrogenase.
• Biochemical Standard & Calibration: Provides a reference standard for calibrating analytical equipment and validating methods in bioanalytical laboratories.

Basic Information

Product Name	D-Glucose-[6-3H(N)]
CAS No.	104903-05-1
Molecular Formula	C6H113HO6
Molecular Weight	~183.2 g/mol (for 3H labeled)
Synonyms	6-Tritio-D-glucose; [6-3H]Glucose; D-[6-3H]Glucose; Tritiated D-Glucose (6-position); (3H)Glucose; Glucose-6-t; Radiolabeled D-Glucose; 6-Tritiated Glucose
EINECS	Contact for details

Quality Control

Every batch of D-Glucose-[6-3H(N)] is manufactured and analyzed under strict quality systems to ensure exceptional radiochemical purity and specific activity. Our quality control protocols include rigorous analysis via HPLC and TLC to confirm identity, purity, and radiochemical concentration, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA), detailing specific activity, purity, solvent composition, and analytical methods, is provided with each shipment to guarantee traceability and reproducibility for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as specified on the label or COA. Due to its light-sensitive nature and the inherent volatility of tritium, appropriate shielding and handling in accordance with local radiation safety regulations are mandatory. The storage area should be well-ventilated and designated for radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless solution
Identification (HPLC/TLC)	Conforms to reference standard
Radiochemical Purity	≥ 97%
Specific Activity	10-40 Ci/mmol (Contact for specific value)
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water (9:1) or as specified
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.