Description

Alpha,β-Methyleneadenosine 5'-Triphosphate Lithium Salt is a chemically modified, non-hydrolyzable analog of adenosine triphosphate (ATP). This compound is critical for biochemical research as it acts as a potent and selective inhibitor of ATP-dependent enzymes, allowing for the study of phosphorylation mechanisms without being metabolized. It is primarily utilized by researchers and scientists in pharmaceutical development, enzymology, and molecular biology for investigating signal transduction pathways and enzyme kinetics.

Application

• Enzyme Inhibition Studies: Used as a stable ATP analog to inhibit ATPases, kinases, and other ATP-binding proteins in mechanistic studies.
• Biochemical Research: Essential tool for probing energy-dependent processes, signal transduction cascades, and nucleotide-binding sites.
• Pharmaceutical Screening: Employed in high-throughput screening assays to identify potential therapeutic compounds that target ATP-utilizing enzymes.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the structure of enzyme-ligand complexes.
• Metabolic Pathway Analysis: Used to dissect and understand complex metabolic networks where ATP is a key substrate or regulator.
• Diagnostic Reagent Development: Serves as a component in developing diagnostic kits for enzyme activity measurements.

Basic Information

Product Name	Alpha,β-Methyleneadenosine 5'-Triphosphate Lithium Salt
CAS No.	104809-20-3
Molecular Formula	C11H14LiN5O12P3
Molecular Weight	529.13 g/mol (Lithium salt form)
Synonyms	α,β-Methylene-ATP Lithium Salt; Adenosine 5'-(α,β-methylene)triphosphate Lithium Salt; AMP-PCP Lithium Salt; Ap(CH2)ppLi; Adenylyl (α,β-methylene)diphosphonate Lithium Salt; Non-hydrolyzable ATP analog Lithium salt; 5'-Adenylyl (α,β-methylenetriphosphate) Lithium salt
EINECS	Contact for details

Quality Control

Our Alpha,β-Methyleneadenosine 5'-Triphosphate Lithium Salt is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water or buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.