Description

Clofibric Acid-Coenzyme A is a critical biochemical conjugate formed from the hypolipidemic agent clofibric acid and coenzyme A, essential for studying its metabolic activation and biological activity. This compound is vital for researchers investigating the mechanisms of fibrate drugs, their metabolic pathways, and potential interactions within cellular systems. It is primarily used by pharmaceutical R&D laboratories, academic research institutions, and biochemical manufacturers focused on lipid metabolism, drug discovery, and enzymology studies.

Application

• Biochemical Research: A key substrate for in vitro studies on the enzymatic conjugation and metabolic fate of fibrate drugs.
• Drug Metabolism Studies: Used to investigate the activation pathway of clofibric acid and its subsequent biological effects.
• Enzyme Assay Development: Serves as a standard or reagent in assays for acyl-CoA synthetases and transferases.
• Mechanistic Toxicology: Employed to study the role of CoA thioester formation in the pharmacological and toxicological profiles of carboxylic acid-containing drugs.
• Reference Standard: Used as a high-purity analytical standard in LC-MS or HPLC methods for quantifying drug metabolites.
• Precursor Synthesis: Acts as a synthetic intermediate for preparing more complex labeled or modified metabolites for advanced research.

Basic Information

Product Name	Clofibric Acid-Coenzyme A
CAS No.	104732-21-0
Molecular Formula	C38H62N7O19P3S
Molecular Weight	1057.91 g/mol
Synonyms	Clofibryl-CoA; Clofibrate Coenzyme A; 2-(4-Chlorophenoxy)-2-methylpropanoyl-CoA; 4-Chlorophenoxyisobutyryl-Coenzyme A; Clofibric Acid CoA; CPIB-CoA; Clofibrate Metabolite CoA Thioester; Acyl-CoA of Clofibric Acid
EINECS	Contact for details

Quality Control

Our Clofibric Acid-Coenzyme A is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. For long-term storage, keep desiccated. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.