Description

3-[2-n-(Biotinyl)Aminoethyldithio]Propanoic Acid is a specialized biotin derivative featuring a cleavable disulfide linker, designed for advanced bioconjugation and targeted delivery applications. This compound is critical for researchers and manufacturers developing next-generation diagnostic assays, targeted therapeutics, and affinity purification systems. It is primarily utilized by the pharmaceutical, biotechnology, and life science research sectors for creating stable, reversible linkages to proteins, peptides, and other biomolecules.

Application

• Bioconjugation Reagent: For site-specific labeling of antibodies, enzymes, and other proteins with biotin via a reducible disulfide bond.
• Targeted Drug Delivery Systems: As a key component in the synthesis of prodrugs or antibody-drug conjugates (ADCs) where controlled release in reducing environments is required.
• Diagnostic Assay Development: Used to create sensitive ELISA, lateral flow, or other immunoassay components where a cleavable detection system is beneficial.
• Affinity Chromatography Ligands: Immobilization onto solid supports for the reversible capture and elution of target molecules.
• Cell Surface Engineering: For introducing biotin groups onto cell membranes for subsequent binding with streptavidin-conjugated molecules.
• Proteomics and Biomolecular Research: As a tool compound for studying protein interactions, trafficking, and turnover through reversible biotinylation.

Basic Information

Product Name	3-[2-n-(Biotinyl)Aminoethyldithio]Propanoic Acid
CAS No.	104582-29-8
Molecular Formula	C17H29N3O4S3
Molecular Weight	435.62 g/mol
Synonyms	Biotin-HPDP; N-[6-(Biotinamido)hexyl]-3'-(2'-pyridyldithio)propionamide (common mis-assignment check); 3-((2-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)disulfanyl)propanoic Acid; Biotinylated HPDP; Biotin-PDP; 1-Biotinamido-4-[4'-(maleimidomethyl)cyclohexanecarboxamido]butane (structural analog); Biotin SS reagent; Biotin disulfide labeling reagent
EINECS	Contact for details

Quality Control

Our 3-[2-n-(Biotinyl)Aminoethyldithio]Propanoic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is light-sensitive and easily oxidized. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.