Description

N(Alpha)-Dansyl-N(Omega)-1,N(6)-Etheno-Adp-Ribosylarginine Methyl Ester is a specialized, high-purity biochemical reagent designed for advanced research applications. This compound serves as a critical tool for scientists studying ADP-ribosylation, a key post-translational modification involved in cellular signaling, DNA repair, and stress response. It is primarily utilized by researchers in the fields of biochemistry, molecular biology, and pharmacology who require precise and reliable probes for enzymatic assays and mechanistic studies.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies of poly(ADP-ribose) polymerases (PARPs) and other ADP-ribosyltransferases.
• Mechanistic Studies: Aids in elucidating the mechanisms of ADP-ribosylation and its role in cellular processes like DNA damage response and chromatin remodeling.
• Assay Development: Serves as a key component in the development of high-throughput screening (HTS) assays for drug discovery targeting PARP enzymes.
• Signal Transduction Research: Employed to investigate the role of ADP-ribosylation in cell signaling pathways relevant to cancer, inflammation, and neurodegeneration.
• Reference Standard: Functions as a chromatographic or spectroscopic reference standard for the identification and quantification of related metabolites.
• Academic & Pharmaceutical R&D: Essential for basic research in academic institutions and for target validation in pharmaceutical research and development pipelines.

Basic Information

Product Name	N(Alpha)-Dansyl-N(Omega)-1,N(6)-Etheno-Adp-Ribosylarginine Methyl Ester
CAS No.	104257-22-9
Molecular Formula	C₃₀H₄₀N₁₀O₁₃P₂S
Molecular Weight	842.73 g/mol
Synonyms	1,N(6)-Etheno-ADP-ribosyl-N(alpha)-dansylarginine methyl ester; Etheno-ADP-ribosyl-dansylarginine methyl ester; N(alpha)-Dansyl-N(omega)-(1,N(6)-etheno-ADP-ribosyl)-L-arginine methyl ester; Dansyl-etheno-ADP-ribosylarginine methyl ester; PARP substrate analog; ADPR-DansylArg-OMe; Research biochemical 104257-22-9
EINECS	Contact for details

Quality Control

Every batch of N(Alpha)-Dansyl-N(Omega)-1,N(6)-Etheno-Adp-Ribosylarginine Methyl Ester is produced and analyzed under strict quality protocols to ensure the highest standards of purity and consistency required for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity confirmation, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.