Description

Manzamine A is a complex marine-derived alkaloid isolated from sponges of the genus Acanthella and Halichondria, renowned for its intricate pentacyclic ring system and potent biological activity. It serves as a high-value pharmacological probe and lead compound in anticancer, antimalarial, and neuroprotective drug discovery programs. Research institutions, pharmaceutical R&D laboratories, and contract research organizations (CROs) rely on rigorously characterized Manzamine A CAS NO 104196-68-1 for target validation, mechanism-of-action studies, and preclinical screening.

Application

• Anticancer drug discovery — evaluation of cytotoxicity against human tumor cell lines (e.g., HCT-116, MCF-7, A549)
• Antimalarial research — inhibition assays targeting Plasmodium falciparum strains, including multidrug-resistant isolates
• Neuropharmacology studies — modulation of neuronal signaling pathways and neuroinflammatory responses
• Chemical biology tool compound — selective inhibition of kinases and protein-protein interactions in pathway mapping
• Structure-activity relationship (SAR) studies — scaffold for semi-synthetic analog development
• Marine natural product reference standard — calibration and method validation in LC-MS/MS and HPLC analyses
• Academic and government-funded biomedical research — NIH, EU Horizon, and JSPS grant-supported projects

Basic Information

Product Name	Manzamine A
CAS No.	104196-68-1
Molecular Formula	C36H44N4O
Molecular Weight	556.76 g/mol
Synonyms	Manzamine A; Manzamine-A; NSC 655649; 104196-68-1; Manzamine A (natural); (3R,4R,5R,6R,7R,8R,9R,10R,11R,12R,13R,14R,15R,16R,17R,18R,19R,20R,21R,22R,23R,24R,25R,26R,27R,28R,29R,30R,31R,32R,33R,34R)-3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34-Dodecahydro-1H-azepino[1,2-a]pyrido[1',2':1,2]imidazo[4,5-h]isoquinoline-1,2(3H)-dione; Manzamine A (purified); Manzamine A (≥98% HPLC)
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Manzamine A are tested per ICH Q5 and Q7 guidelines for biopharmaceutical intermediates, with full traceability, stability-indicating HPLC methods, and spectral confirmation (NMR, HRMS, IR). Purity is verified by orthogonal analytical techniques including UV-HPLC and LC-MS, meeting requirements for research-grade natural products (ACS Grade equivalent).

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent oxidation and degradation. Keep away from moisture and direct sunlight. Handle in a controlled environment with minimal exposure to ambient air during weighing or dispensing.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Identification (HRMS)	[M+H]+ m/z 557.3528 ± 0.005 (C36H45N4O+)
Assay (HPLC-UV)	≥98.0%
Related Substances	≤2.0% total impurities (by HPLC)
Residual Solvents	Meets ICH Q3C Class 3 limits (≤5000 ppm total)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.