Description

2-Allyl-2-Demethyl-Colchicine is a semi-synthetic derivative of the natural alkaloid colchicine, characterized by its modified tropolone ring structure. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a lead compound in the study of anti-inflammatory and anti-mitotic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and synthesis of novel colchicine analogs for therapeutic applications.
• Biochemical Research: Used as a reference standard or probe in studies investigating tubulin polymerization inhibition and cytoskeleton dynamics.
• Anti-inflammatory Agent Development: Acts as a precursor or model compound in the discovery of new treatments for gout and other inflammatory conditions.
• Oncology Research: Investigated for its potential anti-mitotic properties in the development of new chemotherapeutic agents.
• Academic & Contract Research: Employed in university and CRO laboratories for mechanistic studies and structure-activity relationship (SAR) analysis.

Basic Information

Product Name	2-Allyl-2-Demethyl-Colchicine
CAS No.	104158-07-8
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	2-Allyl-2-demethylcolchicine; 2-Allylcolchicine; N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide (modified); Colchicine, 2-allyl-2-demethyl-; Demecolcine analog; 2-ADC; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Allyl-2-Demethyl-Colchicine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research-grade materials. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.