Description

N(3)-Allyluridine is a chemically modified nucleoside derivative, specifically an allyl-substituted uridine analog. This compound is a crucial building block in oligonucleotide synthesis and medicinal chemistry research, enabling the site-specific introduction of functional groups. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for developing novel therapeutics, including antisense oligonucleotides and prodrugs. Its unique structure allows for further chemical modifications, making it a valuable intermediate in advanced drug discovery platforms.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• Prodrug Design: Serves as a versatile intermediate for creating nucleoside-based prodrugs with enhanced bioavailability.
• Bioconjugation & Labeling: The allyl group provides a handle for click chemistry (e.g., thiol-ene reactions) to attach fluorescent tags or other payloads.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies in search of new antiviral or anticancer agents.
• Academic & Institutional Research: Used in biochemistry and molecular biology labs studying nucleic acid structure, function, and modification.

Basic Information

Product Name	N(3)-Allyluridine
CAS No.	103951-13-9
Molecular Formula	C12H16N2O6
Molecular Weight	284.26 g/mol
Synonyms	3-Allyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3-(prop-2-en-1-yl)pyrimidine-2,4(1H,3H)-dione; Allyl Uridine; N3-Allyluridine; Uridine, 3-allyl-
EINECS	Contact for details

Quality Control

Our N(3)-Allyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.