Description

(-)-n-Methylphysostigmine CAS NO 103877-07-2 is a high-purity, stereochemically defined alkaloid derivative of significant interest in advanced pharmacological research and development. This compound serves as a critical reference standard and a key synthetic intermediate for investigating cholinergic systems and acetylcholinesterase activity. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on neuroscience and medicinal chemistry. Our supply ensures consistent quality and reliable availability for critical development workflows.

Application

• Pharmacological Reference Standard: Used as a certified analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Neuroscience Research: A vital tool compound for in vitro and ex vivo studies targeting acetylcholinesterase (AChE) inhibition and cholinergic neurotransmission.
• Medicinal Chemistry Intermediate: Serves as a sophisticated building block for the synthesis of novel analogs and potential therapeutic agents.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) campaigns and enzyme kinetic studies to identify and characterize new modulators.
• Academic Research: Supports fundamental studies in neurochemistry, toxicology, and the mechanisms of cholinesterase inhibitors.

Basic Information

Product Name	(-)-n-Methylphysostigmine
CAS No.	103877-07-2
Molecular Formula	C16H21N3O2
Molecular Weight	287.36 g/mol
Synonyms	(-)-N-Methylphysostigmine; (3aS,8aR)-1,3a,8-Trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N-methylcarbamate; Escroline methylcarbamate, N-methyl-; N-Methylphysostigmine; Physostigmine, N-methyl-; (-)-N(1)-Methylphysostigmine
EINECS	Contact for details

Quality Control

Every batch of (-)-n-Methylphysostigmine is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards for research chemicals. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.