Description

n-(ε-Maleimidocaproyloxy)Sulfosuccinimide (CAS NO 103848-61-9) is a heterobifunctional crosslinking reagent designed for the stable conjugation of biomolecules. Its core value lies in its dual-reactive functionality, featuring a maleimide group for thiol-specific coupling and a sulfosuccinimide ester for amine-specific conjugation, with enhanced water solubility due to the sulfonate group. This compound is essential for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay creation, where precise and stable protein labeling is critical.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For the site-specific conjugation of cytotoxic drugs to monoclonal antibodies via thiol or amine groups.
• Protein-Protein or Protein-Peptide Crosslinking: Enables the creation of stable complexes for structural studies or therapeutic applications.
• Fluorescent or Enzyme Labeling of Antibodies: Used to prepare labeled antibodies for ELISA, flow cytometry, and immunohistochemistry.
• Surface Immobilization of Biomolecules: For functionalizing biosensor chips, microarray slides, or nanoparticles with proteins or peptides.
• Polymer Modification: Introducing reactive handles onto polymers or dendrimers for subsequent bioconjugation in drug delivery systems.
• Stable Mass Tag Labeling in Proteomics: For quantitative mass spectrometry analysis using stable isotope-labeled reagents.

Basic Information

Item	Details
Product Name	n-(ε-Maleimidocaproyloxy)Sulfosuccinimide
CAS No.	103848-61-9
Molecular Formula	C15H18N2O10S
Molecular Weight	418.38 g/mol
Synonyms	Sulfo-EMCS; N-(ε-Maleimidocaproyloxy)sulfosuccinimide ester; Maleimidocaproyloxysulfosuccinimide; EMCS Sulfo NHS ester; 6-((Maleimido)caproyloxy)sulfosuccinimide; Sulfo-NHS-EMC; Water-soluble EMCS; Heterobifunctional crosslinker EMCS sulfonate
EINECS	Contact for details

Quality Control

Our n-(ε-Maleimidocaproyloxy)Sulfosuccinimide is manufactured under strict quality systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.