Description

n-(4-(4-Maleimidophenyl)Butyryl)Phosphatidylethanolamine is a high-purity, functionalized phospholipid derivative designed for advanced bioconjugation and labeling applications. Its core value lies in the maleimide group, which enables specific, covalent coupling to thiol (-SH) groups under mild conditions, making it an essential tool for creating stable, site-specific biomolecular constructs. This reagent is primarily needed by researchers and developers in biopharmaceuticals, diagnostic assay development, and advanced materials science for modifying liposomes, creating targeted drug delivery systems, and functionalizing surfaces.

Application

• Liposome Functionalization: Covalent attachment of targeting ligands (e.g., antibodies, peptides) or reporter molecules to liposomal surfaces for targeted drug delivery.
• Membrane Protein Labeling: Site-specific labeling of cysteine residues in membrane proteins for structural studies or fluorescence imaging.
• Diagnostic Assay Development: Conjugation of phospholipids to enzymes or other signal-generating molecules for use in immunoassays and biosensors.
• Biomaterial Surface Modification: Creating biomimetic coatings on implants or diagnostic devices by anchoring functional phospholipid layers.
• Nanoparticle Conjugation: Functionalizing lipid-based nanoparticles (LNPs) for mRNA or siRNA delivery with targeting moieties.
• Model Membrane Studies: Incorporation into artificial membranes (e.g., supported lipid bilayers) to study protein-lipid interactions with precise chemical handles.

Basic Information

Product Name	n-(4-(4-Maleimidophenyl)Butyryl)Phosphatidylethanolamine
CAS No.	103794-17-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	MPB-PE; 1,2-Diacyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidophenyl)butyramide]; Maleimide-Phenyl-Butyryl Phosphatidylethanolamine; 4-(p-Maleimidophenyl)butyryl Phosphatidylethanolamine; N-[4-(4-Maleimidophenyl)butanoyl]-1,2-diacyl-sn-glycero-3-phosphoethanolamine; Maleimide-derivatized PE; Thiol-reactive phospholipid
EINECS	Contact for details

Quality Control

Our n-(4-(4-Maleimidophenyl)Butyryl)Phosphatidylethanolamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, TLC for identity, and functional activity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (TLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Solvent (for solution forms)	Chloroform or specified solvent
Functional Activity	Reactive towards thiol groups

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.