Description

Linoleoyl Coenzyme A (C18:2) Lithium Salt is a high-purity, chemically defined derivative of coenzyme A (CoA) where the thiol group is esterified with linoleic acid (C18:2, ω-6). This compound serves as a critical biochemical reagent and substrate for studying lipid metabolism, enzyme kinetics, and cellular signaling pathways. It is essential for researchers and manufacturers in pharmaceutical development, metabolic research, and biochemical production requiring precise acyl-CoA substrates.

Application

• Enzymology Research: As a specific substrate for studying acyl-CoA dehydrogenases, synthetases, and transferases involved in fatty acid β-oxidation and lipid biosynthesis.
• Metabolic Pathway Analysis: Used in in vitro assays to investigate disorders of mitochondrial fatty acid metabolism and the role of polyunsaturated fatty acids (PUFAs).
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify potential inhibitors or activators of enzymes targeting lipid metabolism for drug discovery.
• Biochemical Synthesis: Acts as a key building block in the enzymatic synthesis of complex lipids, surfactants, or other specialized biochemicals.
• Cell Signaling Studies: Utilized to explore the role of lipid-derived second messengers and protein acylation in cellular regulation.
• Diagnostic Kit Development: Incorporated as a calibrated reagent in diagnostic kits for measuring specific enzyme activities in clinical samples.

Basic Information

Product Name	Linoleoyl Coenzyme A (C18:2) Lithium Salt
CAS No.	103476-22-8
Molecular Formula	C39H66N7O17P3S • xLi
Molecular Weight	~1057.9 g/mol (Free acid, approximate)
Synonyms	Linoleoyl-CoA Lithium Salt; (9Z,12Z)-Octadeca-9,12-dienoyl-CoA Lithium Salt; Coenzyme A Linoleoyl Ester Lithium Salt; C18:2-CoA Li Salt; Linoleoyl-Coenzyme A Lithium; ω-6 Acyl-CoA Substrate; Lipid Metabolism Substrate
EINECS	Contact for details

Quality Control

Every batch of Linoleoyl Coenzyme A Lithium Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the exacting requirements of research and bioproduction. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Enzymatic/UV)	≥ 90%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.