Description

(2S,3R,4E)-2-Azido-3-Benzoyl-Erythro-Sphingosine CAS NO 103348-50-1 is a key synthetic intermediate and chemical probe derived from the sphingosine backbone, featuring a strategically placed azido group for bioorthogonal click chemistry. This compound is essential for researchers developing and studying sphingolipid metabolism, cell signaling pathways, and novel drug delivery systems. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on lipidomics, chemical biology, and targeted therapeutics.

Application

• Chemical Biology Probe: Used in click chemistry reactions (e.g., CuAAC, SPAAC) to label, track, and study sphingolipids and their roles in cellular processes.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex sphingolipid analogs and potential therapeutic agents targeting cancer and inflammatory diseases.
• Metabolic Pathway Research: Enables the investigation of sphingolipid metabolism, ceramide synthesis, and apoptosis signaling pathways in cell-based assays.
• Glycoconjugate Synthesis: Acts as a precursor for the preparation of azido-functionalized glycosphingolipids for immunological and neurological studies.
• Lipidomics Standard: Employed as a reference standard in mass spectrometry and chromatography for the identification and quantification of related lipid species.
• Drug Delivery System Development: Utilized to create functionalized lipid nanoparticles and liposomes for targeted drug and gene delivery applications.

Basic Information

Product Name	(2S,3R,4E)-2-Azido-3-Benzoyl-Erythro-Sphingosine
CAS No.	103348-50-1
Molecular Formula	C25H30N4O3
Molecular Weight	434.53 g/mol
Synonyms	2-Azido-3-benzoyl-D-erythro-sphingosine; N-Benzoyl-2-azido-D-erythro-sphingosine; 2-Azido-3-benzoylsphingosine; Azidosphingosine benzoyl derivative; Sphingosine, 2-azido-3-benzoyl-, erythro-; (2S,3R)-2-Azido-1,3-dihydroxy-4-octadecene 3-benzoate; Bz-Az-Sph; Chemical Probe for Sphingolipid Metabolism
EINECS	Contact for details

Quality Control

Our (2S,3R,4E)-2-Azido-3-Benzoyl-Erythro-Sphingosine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.