Description

Glutaryl-Gly-Arg-Amc Hcl is a synthetic, fluorogenic peptide substrate designed for the sensitive detection and quantification of specific protease activity. This compound matters for researchers and industrial biochemists who require precise, reliable tools for enzymatic assays and diagnostic development. It is primarily needed by the pharmaceutical, biotechnology, and life science research sectors for applications in drug discovery, biochemical research, and diagnostic kit manufacturing. CAS No. 103213-40-7.

Application

• Protease Activity Assays: A key fluorogenic substrate for the continuous measurement of trypsin, thrombin, and related serine protease activities in vitro.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors as potential therapeutic agents.
• Biochemical Research: Essential for kinetic studies, enzyme characterization, and mechanistic investigations of protease function and regulation.
• Diagnostic Development: Employed in the development of clinical diagnostic assays for conditions involving dysregulated protease activity, such as coagulation disorders.
• Quality Control in Biologics: Used to monitor and ensure the absence or inactivation of specific proteases during the manufacturing of biopharmaceutical products.
• Enzyme Specificity Profiling: Helps in determining the substrate specificity and catalytic efficiency of engineered or novel proteases.

Basic Information

Product Name	Glutaryl-Gly-Arg-Amc Hcl
CAS No.	103213-40-7
Molecular Formula	C₂₂H₃₃ClN₈O₇
Molecular Weight	557.00 g/mol
Synonyms	Glutaryl-Gly-Arg-7-amido-4-methylcoumarin Hydrochloride; Glt-Gly-Arg-AMC•HCl; Boc-Glutaryl-Gly-Arg-AMC Hydrochloride; Glutaryl-Gly-Arg-AMC; Protease Substrate VI; Fluorogenic Substrate for Trypsin/Thrombin; N-Glutaryl-Gly-Arg-7-amido-4-methylcoumarin hydrochloride; Nα-Glutaryl-Gly-Arg-AMC•HCl
EINECS	Contact for details

Quality Control

Our Glutaryl-Gly-Arg-Amc Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for sensitive research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.