Description

Guanosine 5'-Triphosphate 2',3'-Dialdehyde Sodium Salt is a chemically modified nucleotide analog where the ribose sugar moiety of GTP has been oxidized to a dialdehyde. This modification is critical for its primary function as a reactive intermediate and cross-linking agent in biochemical research. It is an essential tool for scientists in molecular biology and enzymology, particularly for studying nucleotide-binding proteins and enzyme active sites. Key industries that utilize this specialized reagent include pharmaceutical R&D, academic research institutions, and diagnostic kit development.

Application

• Biochemical Cross-linking Agent: Used to covalently modify and study the structure-function relationships of GTP-binding proteins (G-proteins), kinases, and polymerases.
• Enzyme Mechanism Studies: Serves as an affinity label or irreversible inhibitor to probe the active sites of enzymes that utilize GTP as a substrate or cofactor.
• Nucleic Acid Research: Employed in the synthesis of modified oligonucleotides or as a precursor for creating nucleotide analogs with specific reactive handles.
• Pharmaceutical Development: Acts as a key intermediate in the research and development of novel antiviral or anticancer therapeutics that target nucleotide metabolism.
• Diagnostic Assay Development: Utilized in the design and production of diagnostic kits for detecting specific enzymes or cellular pathways involving GTP.

Basic Information

Product Name	Guanosine 5'-Triphosphate 2',3'-Dialdehyde Sodium Salt
CAS No.	103192-45-6
Molecular Formula	C10H12N5O14P3Nax (x~2-3)
Molecular Weight	Approx. 605.1 (Free acid, anhydrous basis)
Synonyms	2',3'-Dialdehyde GTP Sodium Salt; GTP Dialdehyde; Periodate-oxidized GTP; oGTP; Guanosine-5'-triphosphate-2',3'-dialdehyde; Oxidized Guanosine Triphosphate; Gp3p Dialdehyde; Reactive GTP Analog
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Triphosphate 2',3'-Dialdehyde Sodium Salt is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity assessment and spectroscopic identification (UV, NMR). A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and impurities is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.