Description

(6S)-Tetrahydro-L-Biopterin Disulfate is a critical, biologically active cofactor essential for enzymatic reactions involving aromatic amino acid hydroxylases. This high-purity compound is vital for research and production processes where the precise regulation of nitric oxide synthesis and neurotransmitter formation is required. It is primarily utilized by the pharmaceutical, biotechnology, and advanced life science research sectors for applications ranging from biochemical research to the development of therapeutic agents.

Application

• Pharmaceutical Intermediates: Serves as a key precursor in the synthesis of specialized pharmaceuticals targeting metabolic and neurological pathways.
• Biochemical Research: Essential cofactor for in vitro studies of phenylalanine, tyrosine, and tryptophan hydroxylases, and nitric oxide synthases.
• Enzyme Activity Assays: Used in diagnostic kits and laboratory tests to measure the activity of enzymes dependent on tetrahydrobiopterin.
• Cell Culture & Media Supplementation: Added to specialized cell culture media to support the growth and function of certain eukaryotic cell lines.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or other chromatographic methods.
• Nutraceutical R&D: Investigated in the research and development of advanced nutraceutical formulations for metabolic support.

Basic Information

Product Name	(6S)-Tetrahydro-L-Biopterin Disulfate
CAS No.	103130-45-6
Molecular Formula	C9H18N6O2 · 2H2SO4
Molecular Weight	474.44 g/mol
Synonyms	(6R)-5,6,7,8-Tetrahydro-L-biopterin Disulfate; (6S)-5,6,7,8-Tetrahydrobiopterin Disulfate; BH4 Disulfate; Sapropterin Disulfate; (6R)-THB Disulfate; 6R-BH4 Disulfate; Tetrahydrobiopterin Dihydrogen Sulfate; L-Erythro-5,6,7,8-Tetrahydrobiopterin Disulfate
EINECS	Contact for details

Quality Control

Every batch of our (6S)-Tetrahydro-L-Biopterin Disulfate is manufactured and tested under strict quality management systems. We ensure compliance with high-purity standards suitable for pharmaceutical research and development. Comprehensive analytical testing, including HPLC for purity and identity confirmation, is performed. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere, such as argon or nitrogen, due to its sensitivity to oxidation and moisture. The product is hygroscopic and light-sensitive; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.