Description

Daptomycin is a cyclic lipopeptide antibiotic belonging to the echinocandin class, known for its potent bactericidal activity against Gram-positive pathogens. Its primary value lies in its unique mechanism of action, which involves rapid membrane depolarization, making it a critical agent for treating serious infections caused by resistant organisms. This product is essential for pharmaceutical manufacturers, research institutions, and contract development organizations involved in the development and production of advanced antibiotic formulations. Daptomycin CAS NO 103060-53-3 represents a high-purity active pharmaceutical ingredient (API) for professional and industrial applications.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of injectable antibiotic formulations.
• Research and development of novel antimicrobial agents and combination therapies.
• Reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Intermediate in the synthesis of more complex lipopeptide derivatives for clinical studies.
• Use in microbiological research to study mechanisms of bacterial resistance and membrane function.
• Component in preclinical studies for evaluating pharmacokinetics and pharmacodynamics.

Basic Information

Product Name	Daptomycin
CAS No.	103060-53-3
Molecular Formula	C72H101N17O26
Molecular Weight	1620.67 g/mol
Synonyms	LY 146032; Cidecin; Cubicin; Dapcin; (3S,6R,9R,12R,15S,18S,21R,24S,27S,30S)-30-[(2R)-2-Aminopentanamido]-27-[(2S)-2-aminopropanamido]-21-benzyl-6-[(1S)-1-carboxy-2-(naphthalen-1-yl)ethyl]-15-[(1R)-1-carboxyethyl]-3-[(1R)-1-hydroxyethyl]-12-isobutyl-18-[(1S)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28-decaoxo-9-(pentan-3-yl)-1,4,7,10,13,16,19,22,25,28-decazacyclotriacontan-24-carboxylic acid
EINECS	Contact for details

Quality Control

Our Daptomycin is manufactured under strict quality systems to ensure it meets the high standards required for pharmaceutical use. Each batch is tested against rigorous specifications, including identity, purity, and potency, with compliance to relevant pharmacopeial guidelines (e.g., USP, EP) where applicable. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C, or under refrigeration at 2-8°C as specified. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.25 EU/mg
Sterility (if applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.