Description

5,10-Methylene-5,6,7,8-Tetrahydro-8,10-Dideazaminopterin is a high-purity, non-classical antifolate compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its potent and selective inhibitory activity against key enzymes, making it a critical intermediate for novel therapeutic agents. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of targeted cancer therapies, antimicrobials, and other precision medicines. We supply this material with a focus on batch-to-batch consistency and reliable documentation to support rigorous R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antifolate drugs targeting dihydrofolate reductase (DHFR) and thymidylate synthase (TS).
• Oncology Research: Investigated as a precursor for developing chemotherapeutic agents with improved selectivity and reduced side-effect profiles.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic studies to understand folate metabolism pathways.
• Antimicrobial Agent Development: Explored for creating new compounds to combat drug-resistant bacterial and parasitic infections.
• Process Chemistry & Scale-Up: Supplied to support chemical development and optimization of synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	5,10-Methylene-5,6,7,8-Tetrahydro-8,10-Dideazaminopterin
CAS No.	103003-96-9
Molecular Formula	C₂₀H₂₃N₇O₅
Molecular Weight	441.44 g/mol
Synonyms	5,10-CH₂-THFA; 5,10-Methylene-5,6,7,8-tetrahydro-8,10-dideazafolic acid; Dideazaminopterin, 5,10-methylene-5,6,7,8-tetrahydro-8,10-; LY231514 impurity; Pemetrexed impurity; Non-classical antifolate; 8,10-Dideaza-5,8-dideazafolic acid derivative
EINECS	Contact for details

Quality Control

Our 5,10-Methylene-5,6,7,8-Tetrahydro-8,10-Dideazaminopterin is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your research or development protocols. Specifications are aligned with the standards required for pharmaceutical intermediates and reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.