Description

N6,2'-o-Disuccinyladenosine 3':5'-Cyclic Monophosphate Sodium Salt is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a crucial secondary messenger in cellular signaling. This succinylated analog is specifically engineered to enhance membrane permeability and stability, making it a valuable tool for modulating intracellular cAMP-dependent pathways in research. It is primarily utilized by researchers in pharmacology, biochemistry, and cell biology for studying protein kinase A (PKA) activation, gene expression regulation, and other signal transduction mechanisms.

Application

• Biochemical Research: As a cell-permeable cAMP analog to activate Protein Kinase A (PKA) and study downstream signaling cascades.
• Pharmacological Studies: For investigating the role of cAMP in cardiac function, neuronal plasticity, and metabolic regulation.
• Cell Culture & Physiology: To probe intracellular responses in various cell lines, including stem cells, cardiomyocytes, and neurons.
• Drug Discovery & Development: Serving as a reference compound or tool molecule for screening and validating targets in cAMP-associated diseases.
• Enzyme Assays: Used as a substrate or modulator in enzymatic studies related to phosphodiesterases and adenylate cyclases.

Basic Information

Product Name	N6,2'-o-Disuccinyladenosine 3':5'-Cyclic Monophosphate Sodium Salt
CAS No.	102783-27-7
Molecular Formula	C23H27N5O15P • xNa
Molecular Weight	Approx. 700-750 g/mol (as sodium salt)
Synonyms	N6,2'-O-Disuccinyl-cAMP sodium salt; Disuccinyl cAMP sodium salt; N6,2'-O-Disuccinyladenosine cyclic 3',5'-(hydrogen phosphate) sodium salt; 2'-O-Succinyladenosine 3',5'-cyclic monophosphate N6-succinate sodium salt; cAMP disuccinate sodium salt; Cell-permeable cAMP analog; 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate analog (related compound); Biologically active cAMP derivative
EINECS	Contact for details

Quality Control

Our N6,2'-o-Disuccinyladenosine 3':5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are available upon request to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO
Biological Activity	Tested in cell-based assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.