Description

9-(2'-Acetoxyethoxymethyl)-Guanine is a key nucleoside analogue derivative and a crucial advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of antiviral and anticancer agents, where its modified structure is essential for imparting specific biological activity and metabolic stability. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the production of novel therapeutic compounds.

Application

• Pharmaceutical Intermediate: A vital building block in the synthesis of novel antiviral and anticancer nucleoside analogues.
• Antiviral Drug Research: Used in the development and scale-up of prodrugs targeting herpesviruses and other viral infections.
• Oncology Research: Serves as a precursor for chemotherapeutic agents that interfere with DNA replication in cancer cells.
• Biochemical Research: Employed in studies of enzyme kinetics and mechanisms involving nucleotide metabolism.
• Process Chemistry: Utilized in route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the preparation of labeled compounds (e.g., deuterated, C13) for pharmacokinetic and metabolic studies.

Basic Information

Product Name	9-(2'-Acetoxyethoxymethyl)-Guanine
CAS No.	102728-64-3
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	9-[(2-Acetoxyethoxy)methyl]guanine; Acyclovir Impurity; 2-Amino-9-[(2-acetoxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one; Ganciclovir related compound; 9-(2-Acetoxyethoxymethyl)guanine; Acyclovir intermediate; BVDU analogue; Nucleoside prodrug intermediate
EINECS	Contact for details

Quality Control

Our 9-(2'-Acetoxyethoxymethyl)-Guanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.