Description

18-Carboxy-19,20-Dinorleukotriene B4 is a specialized leukotriene analog and metabolite, widely recognized for its role as a key biochemical tool in advanced research. This compound is essential for studying inflammatory pathways, eicosanoid metabolism, and receptor interactions. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on immunology and respiratory diseases.

Application

• Biochemical Research: A critical reference standard and analytical tool for investigating leukotriene biosynthesis, metabolism, and degradation pathways.
• Pharmaceutical Development: Used in the discovery and validation of novel anti-inflammatory drug targets and therapeutic agents.
• Diagnostic Assay Development: Serves as a precise calibrant and control in the development of immunoassays (e.g., ELISA) for quantifying inflammatory biomarkers.
• Metabolite Studies: Employed in metabolic profiling and pharmacokinetic studies to understand the fate of leukotriene B4 and related compounds in biological systems.
• Cell Signaling Research: Used to probe and modulate specific receptor-mediated signaling cascades involved in immune and inflammatory responses.

Basic Information

Product Name	18-Carboxy-19,20-Dinorleukotriene B4
CAS No.	102674-12-4
Molecular Formula	C18H28O5
Molecular Weight	324.41 g/mol
Synonyms	18-COOH-19,20-dinor-LTB4; 18-Carboxy-dinor-leukotriene B4; 5S,12R-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid (18-carboxy-19,20-dinor); ω-Carboxy-dinor-LTB4; LTB4 metabolite; 18-COOH-δ19,20-LTB4; 18-Carboxy-19,20-dinor-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
EINECS	Contact for details

Quality Control

Our 18-Carboxy-19,20-Dinorleukotriene B4 is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.