Description

(-)-Huperzine A is a potent, selective, and reversible acetylcholinesterase inhibitor derived from the Chinese club moss *Huperzia serrata*. This high-purity compound is critical for research and development in neuroscience and cognitive health applications. It is primarily utilized by pharmaceutical R&D laboratories, nutraceutical manufacturers, and academic research institutions focused on neurodegenerative conditions.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for Alzheimer's disease and other memory-related disorders.
• Nutraceutical Formulation: Used as a premium cognitive support ingredient in dietary supplements designed to support memory and mental clarity.
• Neuroscience Studies: Essential tool in biochemical and pharmacological research to study cholinergic neurotransmission, enzyme kinetics, and neuroprotective mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in laboratories.
• Biochemical Reagent: Employed in *in vitro* assays to inhibit acetylcholinesterase for diagnostic or screening purposes.

Basic Information

Product Name	(-)-Huperzine A
CAS No.	102518-79-6
Molecular Formula	C15H18N2O
Molecular Weight	242.32 g/mol
Synonyms	Huperzine A; (5R,9R,11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one; Selagine; L-Huperzine A; (-)-Selagine; S-Huperzine A; ZT-1 (prodrug related); HupA
EINECS	Contact for details

Quality Control

Our (-)-Huperzine A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Specific Rotation	-150° to -165° (c=0.5 in MeOH)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤2.0%
Microbiological Analysis	As per customer requirement

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.