Description

2-Demethyl Colchicine is a key colchicine derivative and a vital intermediate in advanced pharmaceutical synthesis. This compound matters for its role in developing novel therapeutic agents and as a reference standard in biochemical research. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on anti-inflammatory and anti-cancer drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel colchicine-based therapeutics and analogs.
• Biochemical Research: Used as a reference standard and tool compound in studies of tubulin polymerization and microtubule dynamics.
• Drug Discovery: Serves as a precursor for developing potential anti-inflammatory and anti-gout agents.
• Mechanistic Studies: Employed in pharmacological research to investigate structure-activity relationships (SAR) of colchicinoids.
• Analytical Standard: Utilized as a high-purity standard for HPLC, LC-MS, and other analytical methods in quality control laboratories.

Basic Information

Product Name	2-Demethyl Colchicine
CAS No.	102491-80-5
Molecular Formula	C21H23NO5
Molecular Weight	369.41 g/mol
Synonyms	N-Desacetyl-N-methylcolchicine; 2-Desmethylcolchicine; Colchicine, 2-demethyl-; 3-[(7S)-1,2,3,10-Tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; Demecolcine derivative; 2-DMC; N-Methyl-N-desacetylcolchicine
EINECS	Contact for details

Quality Control

Our 2-Demethyl Colchicine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.