Description

4,4'-Methylenebis(2-Chloroaniline)-n-Glucuronide is a specific glucuronide conjugate of the aromatic amine 4,4'-Methylenebis(2-chloroaniline) (MOCA). This compound is of significant interest in biochemical and toxicological research as a key metabolite, providing insights into the metabolic pathways and detoxification mechanisms of its parent compound. It serves as a critical reference standard and analytical target for laboratories involved in occupational health monitoring, environmental analysis, and advanced pharmaceutical research. The availability of this high-purity metabolite is essential for ensuring accurate quantification and method validation in complex biological matrices.

Application

• Biomarker Analysis & Occupational Exposure Monitoring: Used as a certified reference standard to quantify MOCA exposure in biological samples (e.g., urine, blood) for workplace safety compliance.
• Toxicology & Metabolism Studies: Essential for investigating the Phase II conjugation (glucuronidation) pathways, pharmacokinetics, and excretion profiles of MOCA.
• Environmental Fate and Risk Assessment: Employed in studies to track the environmental biodegradation and human metabolic processing of chlorinated aromatic amines.
• Pharmaceutical Research: Acts as a critical metabolite standard in drug development programs involving similar amine structures, aiding in ADME (Absorption, Distribution, Metabolism, Excretion) profiling.
• Analytical Method Development & Validation: Serves as a primary calibrant for developing and validating sensitive analytical methods such as LC-MS/MS and HPLC for metabolite detection.
• Quality Control in Reference Material Production: Used by manufacturers of certified reference materials (CRMs) to ensure batch consistency and accuracy for laboratory proficiency testing.

Basic Information

Product Name	4,4'-Methylenebis(2-Chloroaniline)-n-Glucuronide
CAS No.	102411-06-3
Molecular Formula	C20H21Cl2N2O7
Molecular Weight	472.30 g/mol
Synonyms	MOCA Glucuronide; 4,4'-Methylenebis(2-chloroaniline) Glucuronide; 3-[[(4-[(4-Amino-3-chlorophenyl)methyl]-2-chlorophenyl)amino]carbonyl]-β-D-glucopyranuronic acid; MBOCA Glucuronide; Bis-Glucuronide of MOCA; 4,4'-Methylenebis(o-chloroaniline) N-Glucuronide; N-Glucuronide of 4,4'-Methylenebis(2-chloroaniline)
EINECS	Contact for details

Quality Control

Our 4,4'-Methylenebis(2-Chloroaniline)-n-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity analysis and structural confirmation via spectroscopic methods (NMR, MS), to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research or analytical requirements. We support compliance with GLP (Good Laboratory Practice) standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, store at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.