Description

8-Bromoinosine 5'-Diphosphate Sodium Salt is a chemically modified nucleotide analog of significant value in biochemical research and development. This compound serves as a crucial substrate and inhibitor for studying nucleotide-binding enzymes, particularly kinases and ATPases, due to its bromine substitution which alters reactivity and binding affinity. It is primarily utilized by researchers in pharmaceutical discovery, enzymology, and molecular biology for probing enzyme mechanisms and developing novel therapeutic agents.

Application

• Enzyme Kinetics & Mechanism Studies: Used as a substrate analog to investigate the catalytic activity and inhibition profiles of ATP-dependent enzymes like kinases and synthetases.
• Pharmaceutical Research: Serves as a key intermediate or tool compound in the discovery and development of nucleotide-based drugs targeting various diseases.
• Biochemical Assay Development: Employed in the design and validation of high-throughput screening (HTS) assays to identify novel enzyme inhibitors.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the three-dimensional structure of enzyme-ligand complexes.
• Signal Transduction Research: Utilized to modulate and study purinergic signaling pathways in cellular systems.
• Diagnostic Reagent Manufacturing: Acts as a component in the formulation of specialized diagnostic kits for clinical and research laboratories.

Basic Information

Product Name	8-Bromoinosine 5'-Diphosphate Sodium Salt
CAS No.	102185-44-4
Molecular Formula	C10H11BrN4Na2O11P2
Molecular Weight	591.05 g/mol
Synonyms	8-Br-IDP sodium salt; 8-Bromoinosine-5'-diphosphate disodium salt; 8-Bromo-IDP Na2; Inosine 5'-(trihydrogen diphosphate), 8-bromo-, disodium salt; 8-Bromoinosine diphosphate disodium; 8-Br-5'-IDP disodium salt; 8-Bromo-5'-inosine diphosphate sodium salt
EINECS	Contact for details

Quality Control

Our 8-Bromoinosine 5'-Diphosphate Sodium Salt is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.