Description

Adenylyl[2'->5']Adenylyl[2'->5']Adenosine, Sodium Salt is a chemically defined, high-purity nucleotide derivative, specifically a trimer of 2'-5' linked adenosine. This compound is of significant interest for its role as a key intermediate and reference standard in the study of oligoadenylate synthetase pathways and the broader 2-5A system involved in cellular antiviral defense mechanisms. It is primarily utilized by research institutions and pharmaceutical developers focused on immunology, virology, and the development of novel therapeutic agents targeting RNA degradation and interferon-mediated responses.

Application

• Biochemical Research: As a critical substrate or reference standard for studying 2'-5'-oligoadenylate synthetase (OAS) activity and the 2-5A pathway.
• Pharmaceutical R&D: Serving as a key intermediate in the synthesis and development of potential antiviral and immunomodulatory drugs.
• Enzymology Studies: Used to investigate the kinetics and specificity of enzymes involved in nucleotide metabolism and signaling.
• Diagnostic Reagent Manufacturing: A potential component in assay kits designed to detect or quantify components of the innate immune response.
• Cell Signaling Research: For probing intracellular mechanisms related to interferon action and RNAse L activation.
• Academic Research: A vital tool in university and institutional labs exploring fundamental virology and immunology processes.

Basic Information

Product Name	Adenylyl[2'->5']Adenylyl[2'->5']Adenosine, Sodium Salt
CAS No.	102029-70-9
Molecular Formula	C30H36N15O19P2 • xNa
Molecular Weight	Contact for details
Synonyms	2'-5' pppA2'p5'A2'p5'A Sodium Salt; 2-5A Trimer Sodium Salt; P1,P3-Bis(5'-adenosyl) Triphosphate, 2'-5' linked trimer; 2',5'-Oligoadenylate Trimer; 5'-O-[(Phosphonooxy)phosphinyl]adenylyl-(2'->5')-adenylyl-(2'->5')-adenosine Sodium Salt; (2'-5')pppA(pA)2 Na Salt; 2',5'-PPP-A2'P5'A2'P5'A
EINECS	Contact for details

Quality Control

Our Adenylyl[2'->5']Adenylyl[2'->5']Adenosine, Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.