Description

Adenosine 3'-Phosphate 5'-Phosphosulfate, Tetralithium Salt is a high-purity, biologically active nucleotide cofactor essential for enzymatic sulfation reactions. This compound serves as the universal sulfate donor in the biosynthesis of sulfated biomolecules, making it a critical reagent for biochemical research and pharmaceutical development. It is primarily utilized by researchers in biochemistry, molecular biology, and drug discovery, as well as by manufacturers developing enzyme assays and diagnostic kits.

Application

• Enzymology Research: As the sulfate donor for sulfotransferase (SULT) enzymes in kinetic and mechanistic studies.
• Drug Metabolism Studies: Investigating Phase II sulfation pathways for drug candidates and xenobiotics.
• Biochemical Assay Development: A key component in high-throughput screening (HTS) assays for sulfotransferase activity and inhibitor discovery.
• Glycosaminoglycan (GAG) Synthesis: Used in in vitro systems for the biosynthesis of heparin, heparan sulfate, and other sulfated polysaccharides.
• Diagnostic Reagent Manufacturing: Incorporated into clinical diagnostic kits that measure sulfotransferase activity or sulfate metabolism.
• Cell Signaling Research: Studying the role of sulfation in hormone activity, receptor function, and cell-cell communication.

Basic Information

Product Name	Adenosine 3'-Phosphate 5'-Phosphosulfate, Tetralithium Salt
CAS No.	102029-54-9
Molecular Formula	C10H8Li4N5O13P2S
Molecular Weight	555.04 g/mol
Synonyms	PAPS, Tetralithium Salt; 3'-Phosphoadenosine-5'-phosphosulfate, Tetralithium Salt; Adenosine 3',5'-Bisphosphate, Sulfate, Tetralithium Salt; PAPS Li4; 3'-Phosphoadenylyl Sulfate Tetralithium; Adenosine 3'-Phosphate 5'-Sulfatophosphate Tetralithium Salt
EINECS	Contact for details

Quality Control

Our Adenosine 3'-Phosphate 5'-Phosphosulfate, Tetralithium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological suitability. We support research and production needs with material traceability and documentation in compliance with cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity (Enzymatic Assay)	≥ 90% of theoretical
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.