Description

Lithium n-(6-Aminohexyl)-5'-o-(Hydroxyphosphinato)Adenosine 3'-(Dihydrogen Phosphate) is a chemically modified nucleotide analog, specifically designed as a potent and cell-permeable inhibitor of cyclic nucleotide phosphodiesterases. This compound is crucial for biochemical research, enabling precise modulation of intracellular cyclic AMP (cAMP) and cyclic GMP (cGMP) signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies for target validation, enzyme kinetics studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: As a key biochemical tool for studying phosphodiesterase (PDE) enzyme inhibition and cyclic nucleotide signaling cascades.
• Cell Biology & Signal Transduction: Used to elevate intracellular cAMP/cGMP levels in cell culture models to investigate downstream physiological effects.
• Enzyme Kinetics & High-Throughput Screening (HTS): Serves as a reference standard or inhibitor in assays to characterize PDE isoforms and screen for new drug candidates.
• Cardiovascular & Neurobiology Research: Applied in studies related to vasodilation, cardiac contractility, memory, and learning processes where PDEs play a regulatory role.
• Biochemical Reagent Manufacturing: Incorporated into specialized assay kits and research reagents sold to the life science market.

Basic Information

Product Name	Lithium n-(6-Aminohexyl)-5'-o-(Hydroxyphosphinato)Adenosine 3'-(Dihydrogen Phosphate)
CAS No.	102029-47-0
Molecular Formula	C16H28LiN6O11P2
Molecular Weight	549.3 g/mol (Lithium salt form)
Synonyms	6-AHA-cAMPS, Lithium salt; Adenosine-3',5'-cyclic monophosphorothioate, 6-[(Aminohexyl)amino]-, Rp-isomer, Lithium salt; Rp-6-AHA-cAMPS; Rp-Adenosine-3',5'-cyclic monophosphorothioate, 6-[(6-Aminohexyl)amino]-, Lithium salt; PDE Inhibitor (Rp-6-AHA-cAMPS); Rp-6-[(6-Aminohexyl)amino]adenosine-3',5'-cyclic monophosphorothioate Lithium salt; Cell-permeable cAMP analog inhibitor.
EINECS	Contact for details

Quality Control

Our Lithium n-(6-Aminohexyl)-5'-o-(Hydroxyphosphinato)Adenosine 3'-(Dihydrogen Phosphate) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive biochemical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 90% (anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.