Description

Desvancosaminyl Vancomycin is a semi-synthetic glycopeptide antibiotic derivative, representing a significant advancement in the structural modification of vancomycin to combat resistant bacterial strains. This compound is of critical importance for pharmaceutical research and development, particularly in the synthesis of next-generation antibiotics targeting Gram-positive infections. It serves as a key intermediate and reference standard for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors focused on antimicrobial innovation.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of novel vancomycin analogs and next-generation glycopeptide antibiotics.
• Antimicrobial Research: Critical reference standard for studying structure-activity relationships (SAR) and mechanisms of action against resistant bacteria.
• Biochemical Research: Used in enzymatic and microbiological studies to investigate bacterial cell wall synthesis inhibition.
• Analytical Standard: Serves as a high-purity calibrant and control material for HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Process Development: Employed in the development and scaling of fermentation and chemical synthesis processes for complex antibiotics.

Basic Information

Product Name	Desvancosaminyl Vancomycin
CAS No.	101485-50-1
Molecular Formula	C66H75Cl2N9O24
Molecular Weight	1449.2 g/mol
Synonyms	Vancomycin, desvancosaminyl-; Desvancosaminylvancomycin; N-Desvancosaminylvancomycin; (3S,6R,7R,22R,23S,26S,36R,38aS)-26-[(2S,3R,4S,5S,6R)-4-Amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-6-[(2R,3S,4S,5R,6R)-4,5-dihydroxy-3-[(2R,3R,4R,5R,6S)-3-hydroxy-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-4-methyl-6-propyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-22-[(2R)-1-hydroxypropan-2-yl]-23-methyl-3,4,7,10,21,24,35,38a-octahydro-2H,15H-1,20:11,36-dietheno-15,17-metheno-2,7:23,26-[1,11]dioxacyclooctadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-15,17,19,25,27(14H,16H)-pentone
EINECS	Contact for details

Quality Control

Our Desvancosaminyl Vancomycin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.