Description

Doxycycline Hydrochloride CAS NO 100929-47-3 is a broad-spectrum, semi-synthetic tetracycline antibiotic derived from oxytetracycline. It is highly valued for its efficacy against a wide range of Gram-positive and Gram-negative bacteria, mycoplasmas, and certain protozoa. This compound is essential for manufacturers in the pharmaceutical, veterinary medicine, and research sectors, where it is used as the active pharmaceutical ingredient (API) in various formulations.

Application

• Human Pharmaceutical Formulations: Primary API in oral capsules, tablets, and suspensions for treating respiratory infections, acne, Lyme disease, and malaria prophylaxis.
• Veterinary Medicine: Key ingredient in medicated feeds, injectables, and topical preparations for livestock, poultry, and companion animals to combat bacterial infections.
• Research & Development: Used as a critical biochemical tool in microbiological studies, cell culture (as a selection agent), and molecular biology research.
• Aquaculture: Employed in the treatment of bacterial diseases in farmed fish and shellfish.
• Industrial Bioprocessing: Acts as an additive in fermentation processes to prevent bacterial contamination.

Basic Information

Product Name	Doxycycline Hydrochloride
CAS No.	100929-47-3
Molecular Formula	C₂₂H₂₄N₂O₈·HCl
Molecular Weight	480.90 g/mol
Synonyms	Doxycycline HCl; Doxycycline Monohydrochloride; Vibramycin Hydrochloride; GS-3065; (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride; α-6-Deoxy-5-oxytetracycline Hydrochloride; Doxycycline Hydrochloride Hemihydrate Hemiethanolate (common solvate form)
EINECS	Contact for details

Quality Control

Our Doxycycline Hydrochloride is produced under strict quality management systems. Each batch is tested to meet stringent specifications, including identification, purity, and impurity profiles, aligning with major pharmacopoeial standards such as USP, EP, and BP. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and compliance for our customers' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	Yellow to yellow-orange crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC, anhydrous basis)	95.0% - 102.0%
pH (1% solution)	2.0 - 3.0
Water (KF)	≤ 2.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.