Description

Arg-Arg β-Naphthylamide Trihydrochloride is a specialized synthetic peptide derivative, primarily utilized as a chromogenic substrate for the detection and study of trypsin-like proteolytic enzyme activity. This compound is valued for its high sensitivity and specificity in biochemical assays, enabling precise measurement of enzyme kinetics and inhibition. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, diagnostic, and life science sectors, where accurate protease analysis is critical for drug development and biochemical research.

Application

• Protease Activity Assays: A key chromogenic substrate for the spectrophotometric determination of trypsin, thrombin, plasmin, and other serine proteases.
• Diagnostic Reagent Manufacturing: Used in the formulation of diagnostic kits for clinical analysis of blood coagulation disorders and pancreatic function.
• Pharmaceutical Research & Development: Employed in high-throughput screening (HTS) to identify and characterize novel protease inhibitors for therapeutic applications.
• Biochemical Research: Serves as a critical tool for studying enzyme kinetics, mechanism of action, and substrate specificity in academic and industrial laboratories.
• Quality Control in Bioprocessing: Monitors protease activity during the production and purification of biopharmaceuticals like monoclonal antibodies and recombinant proteins.

Basic Information

Product Name	Arg-Arg β-Naphthylamide Trihydrochloride
CAS No.	100900-26-3
Molecular Formula	C₂₂H₃₈Cl₃N₁₀O₃
Molecular Weight	604.96 g/mol
Synonyms	Arg-Arg 2-Naphthylamide trihydrochloride; L-Arginyl-L-arginine 2-naphthylamide trihydrochloride; Bz-Arg-Arg-2NA; BANA; RR-2NA; Nα-Benzoyl-DL-arginine-2-naphthylamide; Protease Substrate BANA; Trypsin Substrate Bz-Arg-Arg-2NA
EINECS	Contact for details

Quality Control

Our Arg-Arg β-Naphthylamide Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent controls for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Biological Activity	Conforms to reference in standard assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.