Description

n-Cbz-Val-Lys-Lys-Arg 4-Methoxy-β-Naphthylamide Trihydrochloride is a specialized, high-purity peptide derivative used as a critical substrate in enzymatic research and diagnostic assay development. This compound matters for its role in studying protease activity, particularly for enzymes like furin and other proprotein convertases, enabling precise biochemical analysis. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on enzyme kinetics, inhibitor screening, and biomarker discovery.

Application

• Protease Substrate: A fluorogenic substrate for the continuous assay of furin and related proprotein convertase enzymes.
• Biochemical Research: Used in kinetic studies to determine enzyme activity, specificity, and inhibition constants (Ki).
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors for therapeutic development.
• Diagnostic Assay Development: Serves as a key component in developing fluorometric assays for detecting specific protease activities in clinical or research samples.
• Cell Biology Studies: Utilized to investigate intracellular proteolytic processing events and signaling pathways.
• Quality Control Reagent: Acts as a reference standard in the quality control of enzyme preparations and diagnostic reagents.

Basic Information

Product Name	n-Cbz-Val-Lys-Lys-Arg 4-Methoxy-β-Naphthylamide Trihydrochloride
CAS No.	100900-15-0
Molecular Formula	C48H73Cl3N12O9
Molecular Weight	1044.5 g/mol
Synonyms	CBZ-Val-Lys-Lys-Arg-4-Methoxy-2-Naphthylamide Trihydrochloride; Z-Val-Lys-Lys-Arg-4-Methoxy-β-NA Trihydrochloride; Furin Substrate; Boc-Val-Lys-Lys-Arg-MNA Trihydrochloride (common naming variant); Nα-Carbobenzoxy-Val-Lys-Lys-Arg-4-Methoxy-2-Naphthylamide Trihydrochloride; Z-V-K-K-R-MNA Trihydrochloride; Proprotein Convertase Substrate; Fluorogenic Peptide Substrate 100900-15-0
EINECS	Contact for details

Quality Control

Our n-Cbz-Val-Lys-Lys-Arg 4-Methoxy-β-Naphthylamide Trihydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.