Description

S-[2-(N7-Guanyl)Ethyl]Glutathione is a specialized biochemical compound, a glutathione conjugate that serves as a critical reference standard and research tool. This compound is essential for studying DNA alkylation damage, adduct formation, and the role of glutathione in cellular detoxification pathways. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors focused on toxicology, carcinogenesis, and biomarker discovery.

Application

• Biomarker Research: Used as a reference standard for the identification and quantification of specific DNA adducts in toxicological studies.
• Metabolic Pathway Analysis: Investigates the conjugation pathways of glutathione with electrophilic agents, crucial for understanding detoxification mechanisms.
• Pharmaceutical Development: Serves as a critical analytical standard in the development and validation of assays for genotoxic impurities.
• Cancer Research: Employed in studies exploring the molecular mechanisms of chemical carcinogenesis and DNA repair processes.
• Reference Material: Provides a high-purity standard for calibrating analytical instrumentation such as HPLC-MS and LC-MS/MS in bioanalytical laboratories.
• Toxicology & Safety Assessment: Essential for assessing exposure biomarkers and understanding the metabolic fate of alkylating agents in biological systems.

Basic Information

Product Name	S-[2-(N7-Guanyl)Ethyl]Glutathione
CAS No.	100840-34-4
Molecular Formula	C17H27N8O6S
Molecular Weight	471.52 g/mol
Synonyms	S-(2-(N7-Guanyl)ethyl)glutathione; N7-Guanine-ethyl-glutathione conjugate; Glutathione-N7-ethylguanine adduct; GSH-N7-EtG; N7-Ethylguanine-glutathione conjugate; S-[2-(7-Guaninyl)ethyl]glutathione; DNA Adduct Standard (GSH-EtG)
EINECS	Contact for details

Quality Control

Our S-[2-(N7-Guanyl)Ethyl]Glutathione is produced under stringent conditions to ensure the highest standards of purity and consistency required for research and analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, verified by advanced chromatographic and spectroscopic methods. We adhere to ISO 9001 quality management principles, and our processes are designed to meet the exacting requirements of pharmaceutical reference standard production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For short-term use, store at 2-8°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.