Description

8-Azidoadenosine Diphosphate Glucose is a chemically modified nucleotide sugar analog, specifically designed as a versatile biochemical tool. This compound is critical for research involving carbohydrate metabolism, enzymatic studies, and the development of novel labeling and detection techniques. It is primarily utilized by scientists and manufacturers in the fields of biochemical research, pharmaceutical development, and diagnostic assay production.

Application

• Biochemical Research: As a substrate analog for studying glycosyltransferase enzymes and carbohydrate-active enzymes.
• Enzyme Mechanism Studies: Used to probe the active sites and catalytic mechanisms of enzymes involved in nucleotide-sugar metabolism.
• Metabolic Pathway Analysis: A tool for tracing and analyzing biosynthetic pathways of complex carbohydrates and glycoconjugates.
• Photoaffinity Labeling: The azido group enables its use as a photo-crosslinking agent for identifying and characterizing protein-ligand interactions.
• Click Chemistry: Serves as a key reagent in bioorthogonal "click" reactions (e.g., CuAAC) for labeling biomolecules with fluorescent or affinity tags.
• Glycobiology & Glycoengineering: Fundamental for synthesizing modified glycans and developing engineered biocatalysts.
• Diagnostic Development: Potential use in the development of diagnostic kits and assays targeting specific enzymatic activities.
• Drug Discovery: Used in high-throughput screening for inhibitors of glycosyltransferases, which are targets for antibiotics, antivirals, and anticancer drugs.

Basic Information

Product Name	8-Azidoadenosine Diphosphate Glucose
CAS No.	100634-21-7
Molecular Formula	C16H23N8O15P2
Molecular Weight	629.35 g/mol
Synonyms	8-Azido-ADP-glucose; 8-N3-ADP-Glucose; Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 8-azido-9-β-D-ribofuranosyl-9H-purine-6-amine, 2'-(dihydrogen phosphate); 8-Azidoadenosine 5'-diphosphoglucose; 8-Azido-ADPG; Azido-ADP-Glc; 8-N3ADP-Glc
EINECS	Contact for details

Quality Control

Our 8-Azidoadenosine Diphosphate Glucose is produced under stringent quality control protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and specifications can be tailored to meet specific research or cGMP starting material requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.