Description

Haloperidol-1-Hydroxy-2'-D-Glucuronide is a major, pharmacologically relevant Phase II metabolite of the widely used antipsychotic drug haloperidol. This compound is of critical importance for pharmaceutical research and development, particularly in the fields of drug metabolism, pharmacokinetics (PK/PD), and bioanalytical method validation. It serves as an essential reference standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors, enabling accurate quantification and study of haloperidol's metabolic pathways.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative analysis of haloperidol and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for in vitro and in vivo studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of haloperidol.
• Bioanalytical Method Development & Validation: Used as a calibrator and quality control (QC) sample in LC-MS/MS, HPLC, and other chromatographic assays to ensure method accuracy and precision.
• Toxicology and Safety Assessment: Employed in studies to investigate the safety profile and potential toxicity associated with haloperidol's metabolic products.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and clinical trials by providing a benchmark for metabolite concentration measurements in patient samples.
• Academic and Government Research: Used in universities and regulatory agency labs for fundamental research on neuroleptic drugs and glucuronidation pathways.

Basic Information

Product Name	Haloperidol-1-Hydroxy-2'-D-Glucuronide
CAS No.	100442-86-2
Molecular Formula	C27H34ClFNO9
Molecular Weight	570.01 g/mol
Synonyms	1-Hydroxyhaloperidol Glucuronide; Haloperidol 1-Hydroxy-2'-D-Glucuronide; Haloperidol Metabolite II Glucuronide; Reduced Haloperidol Glucuronide; HP-Gluc; 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl β-D-Glucopyranosiduronic Acid; 1-β-D-Glucuronyloxy-4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidinium, Inner Salt
EINECS	Contact for details

Quality Control

Our Haloperidol-1-Hydroxy-2'-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, LC-MS, and NMR, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) detailing purity, impurities, and analytical results. Our quality commitment aligns with the standards expected for pharmaceutical reference materials, supporting GLP and GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.