Description

Bilirubin Dimethyl Ester is a chemically modified derivative of bilirubin, a key heme catabolite, where the carboxylic acid groups are esterified with methanol. This modification enhances its stability and solubility in organic matrices, making it a crucial reference standard and synthetic intermediate for advanced research and development. It is primarily utilized by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic research institutions focusing on liver function, jaundice, and metabolic pathway studies.

Application

• Pharmaceutical Reference Standard: Used for the calibration, validation, and quality control of analytical methods (HPLC, LC-MS) in drug development and bioanalytical studies.
• Biochemical Research: Serves as a critical precursor or model compound in studies of bilirubin metabolism, transport, and its role in neonatal jaundice.
• Diagnostic Reagent Manufacturing: Employed in the synthesis and formulation of calibrators and controls for clinical chemistry assays measuring bilirubin levels.
• Organic Synthesis Intermediate: Acts as a protected form of bilirubin for the synthesis of more complex bilirubin analogs or conjugates for specialized research applications.
• Photodynamic Therapy (PDT) Research: Investigated as a potential photosensitizer precursor due to bilirubin's light-absorbing properties.

Basic Information

Product Name	Bilirubin Dimethyl Ester
CAS No.	19792-68-8
Molecular Formula	C₃₃H₃₆N₄O₆
Molecular Weight	572.67 g/mol
Synonyms	Bilirubin IXα Dimethyl Ester; Dimethyl Bilirubin-IXα; 3,18-Diethyl-1,19-dihydro-1,19-dioxo-4,17-vinyliden-21H-biline-8,12-dipropanoic Acid Dimethyl Ester; 2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropionic Acid Dimethyl Ester; Bilirubin Dimethyl Ether (obsolete); NSC 403079; UNII-9FUA7E8U0C
EINECS	Contact for details

Quality Control

Our Bilirubin Dimethyl Ester is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications and test results (including HPLC purity, identity by IR and NMR) are provided and available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.