Description

6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4,9(11)-Triene-3,20-Dione 21-Acetate is a high-purity synthetic steroid derivative, serving as a critical advanced pharmaceutical intermediate. Its primary value lies in enabling the synthesis of potent glucocorticoid receptor agonists with enhanced anti-inflammatory activity and metabolic stability. This compound is essential for research and development laboratories and production facilities in the pharmaceutical industry, particularly those focused on developing next-generation corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluorinated corticosteroid drugs, such as dexamethasone and betamethasone derivatives.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research to develop new therapeutic agents for treating autoimmune disorders, severe allergies, and inflammatory conditions.
• Steroid Chemistry Development: Serves as a reference standard and starting material for medicinal chemists exploring structure-activity relationships (SAR) in the steroid class.
• Active Pharmaceutical Ingredient (API) Synthesis: Integral in multi-step synthesis pathways for manufacturing bulk corticosteroid APIs under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor binding, gene expression modulation, and metabolic pathways.

Basic Information

Product Name	6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4,9(11)-Triene-3,20-Dione 21-Acetate
CAS No.	19788-77-3
Molecular Formula	C₂₄H₂₉FO₆
Molecular Weight	432.49 g/mol
Synonyms	6α-Fluoro-16α-methylprednisolone 21-acetate; 6α-Fluoro-16α-methyl-1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione 21-acetate; 6α-Fluoro-16α-methyl-δ¹,⁴,⁹(¹¹)-pregnen-17α,21-diol-3,20-dione 21-acetate; 6α-Fluoro-16α-methyl-1,4,9(11)-triene-17α,21-dihydroxypregnane-3,20-dione 21-acetate; 6-Fluoro-16-methylprednisolone 21-acetate; 6α-Fluoro-16α-methylprednisolone acetate; 6α-Fluoro-16α-methyl-1,4,9(11)-triene-3,20-dione-17α,21-diol 21-acetate
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoro-17,21-Dihydroxy-16Alpha-Methylpregna-1,4,9(11)-Triene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for residual solvents and related substances. We provide comprehensive Certificates of Analysis (COA) to ensure traceability and compliance with your research or GMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.