Description

Seneciphyllin is a naturally occurring pyrrolizidine alkaloid (PA) derived from specific plant species within the *Senecio* genus. This compound is of significant interest in research and development due to its distinct chemical structure and biological activity profile. It serves as a critical reference standard and intermediate for researchers in the pharmaceutical, toxicology, and natural product chemistry sectors, where precise chemical identity and purity are paramount for analytical and investigative work.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of pyrrolizidine alkaloids in drug discovery, herbal medicine quality control, and regulatory compliance testing.
• Toxicological Research: Employed in studies investigating the hepatotoxic and genotoxic mechanisms of pyrrolizidine alkaloids, crucial for safety assessments in food, feed, and herbal supplements.
• Natural Product Chemistry: Serves as a key intermediate or analytical marker in the isolation, characterization, and synthesis of complex plant-derived alkaloids.
• Analytical Method Development: Essential for developing and validating analytical methods such as HPLC, LC-MS, and GC-MS for the detection and quantification of PAs in complex matrices.
• Biochemical Research: Utilized in enzymatic studies and as a probe to understand specific biological pathways and interactions at the molecular level.

Basic Information

Product Name	Seneciphyllin
CAS No.	19776-79-5
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	Seneciphylline; 12,18-Epoxy-5,6,11,14,15,16-hexahydro-8,10,17-trimethoxy-6-methyl-4H,8H-[1,3]dioxolo[4,5-h]pyrrolizino[1,2-b]isoquinolin-4-one; (13aR)-3,4,5,6,11,13a-Hexahydro-9,10-dimethoxy-3-methyl-6-oxo-12H-[1,3]dioxolo[4,5-h]pyrrolizino[1,2-b]isoquinolin-12-yl methyl carbonate; Retrorsine N-oxide (ambiguous); PA Reference Standard
EINECS	Contact for details

Quality Control

Our Seneciphyllin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR, MS) and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.