Description

(-)-Bicuculline is a potent and specific competitive antagonist of the GABAA receptor, widely recognized as a crucial pharmacological tool in neuroscience research. Its high selectivity makes it indispensable for studying inhibitory neurotransmission, synaptic plasticity, and the mechanisms underlying various neurological disorders. This compound is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuropharmacology and central nervous system drug discovery.

Application

• Neuroscience Research: A fundamental tool for investigating GABAergic inhibition, neuronal excitability, and the role of GABAA receptors in brain circuitry.
• Pharmacological Studies: Used to induce seizures in animal models for the study of epilepsy and to evaluate the efficacy of novel anticonvulsant drugs.
• Neurophysiology: Applied in electrophysiological experiments, such as patch-clamp recordings, to block GABAA receptor-mediated currents.
• Drug Discovery & Development: Serves as a reference standard and screening tool in the development of new therapeutics targeting neurological and psychiatric conditions.
• Biochemical Assays: Used in receptor binding assays and other in vitro tests to characterize ligand-receptor interactions at the GABAA site.

Basic Information

Product Name	(-)-Bicuculline
CAS No.	19730-80-4
Molecular Formula	C20H17NO6
Molecular Weight	367.35 g/mol
Synonyms	(-)-Bicuculline; (S)-(-)-Bicuculline; Bicuculline; NSC 22445; L-Bicuculline; (1S)-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
EINECS	243-273-5

Quality Control

Our (-)-Bicuculline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for advanced research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-130° to -135° (c=1 in CHCl3)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.