Description

n-Desmethyl Dextrorphan -D-o-Glucuronide is a key glucuronide metabolite of dextrorphan, the primary active metabolite of the antitussive drug dextromethorphan. This compound is of significant value in pharmaceutical research and development, particularly for metabolic profiling and pharmacokinetic studies. It is essential for laboratories and manufacturers focused on drug metabolism, forensic toxicology, and the development of analytical reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of dextromethorphan/dextrorphan metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in in vitro and in vivo studies to understand the metabolic pathways, clearance rates, and bioavailability of dextromethorphan.
• Forensic and Clinical Toxicology: A critical calibrant for accurate LC-MS/MS or HPLC analysis in urine drug testing and post-mortem investigations.
• Biomarker Research: Employed in studies correlating metabolite levels with drug efficacy, safety, or abuse potential.
• Enzyme Activity Assays: Used as a substrate to study the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in Phase II drug conjugation.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in regulatory-compliant laboratories.

Basic Information

Product Name	n-Desmethyl Dextrorphan -D-o-Glucuronide
CAS No.	19153-89-0
Molecular Formula	C22H27NO8
Molecular Weight	433.45 g/mol
Synonyms	Dextrorphan O-Glucuronide; Dextrorphan Glucuronide; Dextrorphan β-D-Glucuronide; (9α,13α,14α)-3-Methoxy-17-methylmorphinan-17-ium-6-ol β-D-Glucopyranosiduronic Acid; 17-Methylmorphinan-3-ol, 17-β-D-Glucopyranosiduronic Acid; Nor-Dextrorphan Glucuronide; Dextrorphan Metabolite
EINECS	Contact for details

Quality Control

Our n-Desmethyl Dextrorphan -D-o-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for purity, impurities, and water content is provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Individual impurity ≤2.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.