Description

5α,6-Anhydro Minocycline is a key chemical intermediate and derivative of the broad-spectrum tetracycline antibiotic, minocycline. This compound is of significant interest in pharmaceutical research and development for the synthesis of novel antibiotic analogs and for studying structure-activity relationships. It serves as a critical building block for medicinal chemists and researchers in the life sciences sector. The material is essential for applications requiring high-purity synthetic precursors in antibiotic development and advanced biochemical studies.

Application

• Pharmaceutical Intermediate: Primary use as a high-value synthetic precursor in the research and development of novel tetracycline-class antibiotics and derivatives.
• Medicinal Chemistry Research: A crucial reagent for studying the structure-activity relationship (SAR) of minocycline analogs to enhance efficacy or reduce side effects.
• Biochemical Research: Used in laboratory studies to investigate bacterial resistance mechanisms and the mode of action of tetracycline antibiotics.
• Reference Standard: Serves as a certified reference material (CRM) or analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.
• API Synthesis: Employed in the complex multi-step synthesis of Active Pharmaceutical Ingredients (APIs) within the antibiotic category.

Basic Information

Product Name	5α,6-Anhydro Minocycline
CAS No.	19119-14-3
Molecular Formula	C₂₃H₂₇N₃O₆
Molecular Weight	441.48 g/mol
Synonyms	5α,6-Anhydro-7-dimethylamino-6-demethyl-6-deoxytetracycline; 5α,6-Anhydro-6-demethyl-6-deoxytetracycline; 5α,6-Anhydro-6-deoxyminocycline; Anhydro Minocycline; 5α,6-Anhydro-7-dimethylaminotetracycline; 5α,6-Anhydro-6-deoxy-6-demethyltetracycline; 5α,6-Anhydro-6-demethyl-6-deoxytetracycline; 5α,6-Anhydro-6-deoxyminocycline Hydrochloride (salt form reference)
EINECS	Contact for details

Quality Control

Our 5α,6-Anhydro Minocycline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. We provide detailed Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.